The continuous innovation of the biopharmaceutical industry has led to development of a new category of biopharmaceuticals, biobetters. They are one of the hottest research directions for addressing unmet needs of better clinical outcomes and reduced cost burden on healthcare systems. During the biobetter discovery, in vitro bioassays are necessary to ensure the continued quality, safety, and efficacy, and also for the confirmation of the biocompatibility of the products.
Creative Biolabs, with years’ experience in delivering comprehensive solutions for biobetter discovery, has assisted global clients with critical technical and regulatory guidance at all stages of biobetter development ranging from discovery to cGMP production. The expert team has invested great effort in addressing the variability issue in cell-based bioassays, and has developed a number of novel technologies and ready-to-use bioassay kits.
The products are based on a set of cell-based bioassay platform methods that can be customized for any specific biobetter molecule project, covering custom potency assays, antibody-dependent cell-mediated cytotoxicity (ADCC) assays, antibody-dependent cellular phagocytosis (ADCP) assays, complement-dependent cytotoxicity (CDC) assays, and immune cell assays.
Featured kits are listed below:
* GSH Assay Kit (Colorimetric)
Applications: For detecting the decrease in GSH content during apoptosis and other pathological processes
Features: Fast and convenient (takes only ~1-2 hours); specific (NOT detect oxidized GSSG); sensitive (detect as low as 50 pmol GSH)
Applications: Measurement of intracellular levels of ROS; microplate reader; microscope with TRITC channel; flow cytometry (FL1 channel)
Features: Quick and easy agreement; unique fluorescent probe H2DCFDA; safe(no radioactivity, no special treatment required); high throughput; accurate and repeatable results
* Superoxide Dismutase (SOD) Activity Assay Kit
Applications: Quantitative determination of Superoxide Dismutase (SOD) enzyme activity
Features: Easy-to-use; fast protocol
“We understand that what you do every day is challenging, so we aspire to be a company that is easy for you to work with. Especially for biobetter development, we are confident in providing support for the whole development, optimization, identification and verification of key bioassays,” introduced by a senior scientist, “we ensure you the reliable results in measuring the cell growth, cell death, biomarker expression, induction or inhibition of signaling events, and more.”
The product list also includes GFP quantitation kit, cell fractionation kit, collagen assay kit, etc. Detailed information can be found at https://adcc.creative-biolabs.com/.
About Creative Biolabs
With more than a decade of exploration and expansion, Creative Biolabs has gathered a team of experts with solid knowledge regarding ADCC/CDC-enhanced therapeutic antibody discovery and development. Powered by Afuco™ technology, Creative Biolabs is confident to provide fully integrated solutions of expression optimization, recombinant protein production, antibody ADCC/CDC modification design, or cell line development.